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Antiretroviral cause birth defect risk

HIV positive mothers can be a viral infection to protect their children, if they get antiretroviral drugs during pregnancy. However, even these drugs to prevent the spread of this disease are children, they may cause cleft lip and palate and other birth defects. A new study published in the Journal craniofacial cleft palate in January, will investigate the interaction between antiretroviral prophylaxis and cleft lip and palate.
To establish a drug and use the "report odds than the potential link between birth defects, the researchers studied five years of data from the U.S. Food and reporting system, Drug Administration of adverse events (AERS), pharmacovigilance database publicly available sources.
Antiretroviral drug therapy is to reduce the 15-25% of children the risk of transmission of HIV from mother to less than 1%, but even this success rate is now as a standard treatment with antiretroviral drugs, drugs not classified as safe as a class of drugs, the safety of use during pregnancy. Should therefore continue to investigate to assess the potential risks for the unborn child.
The results of this study identified 26 new cleft lip and cleft palate related to antiviral drugs, ie, lamivudine, efavirenz, nelfinavir, abacavir / as sulfate / laminudine, / zidovudine combination of events. Although the drug is reported to have high odds ratio, it is no evidence that they cause deformity, but they, as an indicator of a potential contact.
Cleft lip and palate is considered for several reasons, such as genetic and environmental factors, a genetic deformity. However, poor nutrition, excessive vitamin A intake and other vitamin and mineral deficiencies can also contribute to its development. Further research is needed to determine whether the association between antiretroviral drugs and cleft lip and palate.

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