Statin Use Linked to Better Post-Stroke Discharge Status

May 22, 2012 - ischemic stroke, the statins are not emptying the house of the body were more likely than non-users, a new study shows. Those who continue to take statins in the hospital, are more likely to go home.On the contrary, the withdrawal of statins in the hospital, was discharged on reducing the risk of home study.- Live in - Statin drugs, lead author Alexander C. The results show that the importance of the risk of stroke in the same queue with previous findings, the relationship between statin use and long-term survival. Flint, Ph.D., Kaiser Permanente Redwood City in the neurological intensive care and stroke doctor, California.Studies showed that statin therapy should begin as soon as possible, Flint said: Medscape Medical News. If, as an outpatient or discharge in ischemic stroke patients. We believe that we need to move, and said it should begin as soon as hospitalization for stroke, should statins. "Study published in the May 22 issue of Neurology.Discharge status12.689 patients with ischemic stroke in the study over 50 years with effect from 17 December 31 January 1, 2000 and 2007, more than 7 years from the tail, an integrated health system hospitals, including Kaiser Permanente of Northern California.Electronic health records and pharmacy records, scientists collect information about. The primary endpoint was the patient discharged from hospital Category: Home, institutions (care institutions and rehabilitation agencies), or died in hospital.Researchers stroke hospitalization, statin users more households (54.6% vs. 50.0%, statins, nonuser) and (7.6% and 8.6% of the unused, p <.001) is less than that found in the hospital dying.Households (47.3% vs. 56.5%) higher, and (5.5% vs. 10.6%, p <0.001) in the hospital before dying, and even less in patients using statins during hospitalization.After adjustment for the statins and improved discharge performance closely, age, gender, race / ethnicity, medical conditions coexist, medical centers, including the potential confounding factors, related to the use.Statins, stroke, and perhaps even more important to recognize that to protect the. If you select this option, "Obviously, statins before and during the best of circumstances, but, if you have had a stroke, not on statins, especially Dover, Dr. Lin Te seems to statins in the hospital said:" Early in hospitals, as a real value for money there.... If you have a stroke, not on statins, is a real value of money, especially early in the hospital, the hospital seems to statins."Previous studies found to improve short-term emission disposal, because if there is a long-term survival, hospital, monitoring, and as soon as possible with better results, in this study.Patients with stroke, statins may not require, because the risk assessment process is not considered high risk, said Dr. Flint. For example, stroke or coronary events than ever before.The use of discharge status as a result of Flint supports tagging feature noted in the literature in the past.Statin use and develop the study design to support a causal relationship between the emission conditions. Two different methods were considered before the analysis, treatment group, using the final process-oriented, drawing a mixture of the patient.Flint: analysis of these technologies, therefore, has essentially including the individual patient's treatment assignment is the statistical model. That rate is likely to affect the results of group therapy with statins is responsible for hospital use, he added.Dr. Flint said thanks to these methods, the researchers confirmed the good results with the use of statins, statin withdrawal of the connection between drugs and poor results.Increasing body of literature by the study emphasized the importance of statins in patients with stroke adds. To reduce the risk of another event, "We have a stroke, was discharged from hospital, her statin drugs, I know I gotta put it," he said.When did you startThe problem is that treatment should be initiated. Some doctors, primary care physicians, post-discharge follow-up began with the treatment we recommend, but the principles of the program at least until the patient's primary care physician may be appropriate to discharge, without having to wait, to start statin recommendation, said Dr. Flint."The problem becomes, it is not enough, we need to put them in one day, one day, they go to the hospital for?"In that study, said that the show is the best way. Statins affect emissions from the alienation of a stroke a few days in the hospital, whether or not another stroke, affects your life. "It takes longer to this mechanism, because this protective effect may be a mechanism to said low-cholesterol. In contrast, the use of statins before and during the ischemic stroke hospitalizaiton anti-inflammatory, vasodilator, and has pleiotropic effects, including the anticoagulant properties.Flint, researchers said the next step is to look at the use of statins in patients with hemorrhagic stroke. He said: "We have only the long-awaited hemorrhagic stroke, it will guide our treatment, then you will see how the hospital is a pleiotropic effect of the potential protective effects of the same?"Future research will be similar to the present, the researchers will use statistical methods like working with a large group of patients.Flint said that it will look 30-day mortality and hospital discharge.Practical informationJosé Biller, MD, Professor and Head, Department of Neurology, Loyola University Chicago, a member of the Commonwealth of Independent States Neurology and Medicine, Maywood, Illinois School Stritch School, said when asked to comment, but the study has some important limitations, interesting and contains some useful information .First of all, rather than short-term and long-term results of the study based on monitoring. The State Statistics Institute of Health Stroke Scale score, stroke, or that do not determine, because in addition to the severity of the stroke and can not provide the cause of stroke.Another disadvantage Modified Rankin Scale to assess the results of study did not include data capabilities is. Placed in an institution of this work better, because some patients may have been not at home, but a better support system in place or have a helpful husband, because he said Bileboshi.Determine compliance with outpatient use of statins and noted that he can not come.He is one advantage of working with exceptional and highly reliable system in the Northern California Kaiser Permanente medical and pharmaceutical magazine The use of "he said.Bileboshi, treatment group analysis of statin drugs in an individual patient deteriorated markedly after the withdrawal of the results of the analysis is important to explain that, but it is not. Nevertheless, it is recommended to prevent the withdrawal of statins in patients at the hospital, he said.He then swallow a stroke because some patients stated that statin drugs may have been canceled. "Statins do not no intravenous formulation," he said.Bileboshi the "fit" to find that a particular statin discourage. He said, "Therefore, if a class effect," the selection of individual drugs in different situations, such as cost and availability of renal function, he said can be based.Bileboshi also taking statins, stressed that the only way to reduce the risk of stroke. "We just do not give a drug to reduce risk, excessive alcohol, tobacco, etc., avoiding exercise, weight control, to ensure that patients, requires a lifestyle consultant, all-inclusive," he said.Because the benefits of C-reactive protein in biological and endothelial function, and the promotion of plaque stabilization is included, will be helpful if the inflammatory response to change the restoration of the statins, including low-cholesterol additional material information, said Dr. Biller.Recent studies of patients taking statins was useful information to their original risk of diabetes blood glucose, glycosylated hemoglobin, and show that it can increase the Bileboshi said.This research Disease Control and Prevention and Kaiser Permanente's Community Welfare Fund Center is funded by the Centers. And any financial relationships Boshibile Flint explained.